Hi John,
If your lakeFS instance is deployed within a specific AWS region, it makes sense to use that same region in your SDK configuration. This can help with potential latency optimizations.
If your buckets(repositories) reside in a specific region, aligning your S3 SDK region setting to that location could also be beneficial.
If you set an incorrect region in your S3 SDK, you might still be able to access your data through lakeFS, but you could experience increased network latency.